I think the trick would be to make the characters as realistic as possible; there's plenty of stories where the characters are all terrible people. The trick is to not make them so one-sided; all people have flaws and strengths, even if they have more flaws. Bojack Horseman, Breaking Bad, It's Always Sunny in Philadelphia, Nightcrawler, etc. etc. are all fantastic yet the characters (primarily the main ones) are horrible, awful people. So yeah, I think you can get away with it.