Hm, in this scenario would we be as ourselves now (i.e. normal human) or would we be molded to fit in the world with powers and such (like in many anime of this genre)?
Assuming I'm coming in as a normal human with the physical and mental capabilities/skills as I have they would be: The Ones Within, Dimension W, Tears of Themis, and dotHack. I think that any futuristic or slice of life anime is a safe bet since it's more or less free of all the real life issues we're having now. Granted, they have their own issues but I consider myself capable enough to resolve the hurdles of those particular universes.
If I was adapted to having abilities comparable to the main cast of a particular media (let's say, being a shinobi in the Naruto universe), my picks would be: Jujutsu Kaisen, Genshin Impact, Destiny franchise, and Paradox Live. They all have very compelling storylines and I find the world building interesting enough that I would want to engage in them as a major player. Although I think Genshin Impact might be cheating since one of them is technically an Isekai already haha.
I can go more in-depth with each pick but I don't want to turn this into an essay lol.